Role of the ataxia-telangiectasia gene (ATM) in breast cancer. A-T heterozygotes seem to have an increased risk but its size is unknown.
作者信息
Lavin M
出版信息
BMJ. 1998 Aug 22;317(7157):486-7. doi: 10.1136/bmj.317.7157.486.
Abstract
摘要
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Role of the ataxia-telangiectasia gene (ATM) in breast cancer. A-T heterozygotes seem to have an increased risk but its size is unknown.共济失调毛细血管扩张症基因（ATM）在乳腺癌中的作用。共济失调毛细血管扩张症杂合子似乎风险增加，但其程度未知。
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本文引用的文献
1
Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.双重保障：p53、BRCA与癌症。p53突变可部分挽救Brca1和Brca2基因敲除小鼠的发育停滞，提示家族性乳腺癌基因在DNA损伤修复中发挥作用。
Nat Med. 1997 Jul;3(7):721-2. doi: 10.1038/nm0797-721.
2
Heterozygous ATM mutations do not contribute to early onset of breast cancer.杂合性 ATM 突变与乳腺癌的早发无关。
Nat Genet. 1997 Mar;15(3):307-10. doi: 10.1038/ng0397-307.
3
AT-tributable risks?
Nat Genet. 1997 Mar;15(3):226. doi: 10.1038/ng0397-226.
4
Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer.分子基因分型显示，共济失调毛细血管扩张症杂合子易患乳腺癌。
Cancer Genet Cytogenet. 1996 Dec;92(2):130-4. doi: 10.1016/s0165-4608(96)00328-7.
5
Comparative study of radiation-induced G2 phase delay and chromatid damage in families with ataxia-telangiectasia.
Cancer Genet Cytogenet. 1994 Aug;76(1):43-6. doi: 10.1016/0165-4608(94)90069-8.
6
Cancer risks in A-T heterozygotes.
Int J Radiat Biol. 1994 Dec;66(6 Suppl):S177-82. doi: 10.1080/09553009414552011.
7
A single ataxia telangiectasia gene with a product similar to PI-3 kinase.一个与PI-3激酶产物相似的共济失调毛细血管扩张症基因。
Science. 1995 Jun 23;268(5218):1749-53. doi: 10.1126/science.7792600.
8
The genetics of breast and ovarian cancer.乳腺癌和卵巢癌的遗传学
Br J Cancer. 1995 Oct;72(4):805-12. doi: 10.1038/bjc.1995.417.
9
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10
Breast cancer and other cancers in Norwegian families with ataxia-telangiectasia.
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