Rénier J C, Fanello S, Rodriguez N, Audran M
Department of Rheumatology, Teaching Hospital, Angers, France.
Rev Rhum Engl Ed. 1995 Oct;62(9):571-5.
To study the prevalence of Paget's disease in a region of France (Anjou) we conducted a two-part study. 1) One hundred randomly selected medical records of Paget's disease patients managed in a rheumatology department were studied to determine the rates of occurrence of pagetic lesions at each skeletal site. Availability of a radionuclide bone scan done before treatment initiation and of radiographs of hyperactive areas was required for inclusion into the study. In 91% of patients, pagetic lesions were visible on the lumbar spine-pelvis-femoral head film. 2) We looked for pagetic lesions on intravenous urograms done in 600 urology department patients (to minimize recruitment bias). The 307 males and 293 females had a mean age of 65.4 +/- 8.7 years (range 50-91). Films classified by the evaluator as showing definite or doubtful pagetic lesions were read by five other evaluators in a blind manner. Among the 11 patients (seven males and four females) found to have Paget's disease, only one was younger than 65 years. Prevalence was higher in males (2.50 +/- 0.79% than in females (1.50 +/- 0.5%). These prevalences are lower than those reported in the United Kingdom.
