Krasnow R E, Wong L L, Adler P N
Biology Department, University of Virginia, Charlottesville 22903, USA.
Development. 1995 Dec;121(12):4095-102. doi: 10.1242/dev.121.12.4095.
The tissue polarity genes in Drosophila are required to coordinate cell polarity within the plane of the epidermis. Evidence to date suggests that these genes may encode components of a novel signal transduction pathway. Three of the genes, frizzled (fz), dishevelled (dsh), and prickle (pk) share a similar tissue polarity phenotype, suggesting that they function together in a single process. dsh is also known to function as a mediator of wingless (wg) signaling in a variety of developmental patterning processes in the fly. In this study, we make use of a fz transgene and a hypomorphic fz allele as genetic tools in an attempt to order these genes in a genetic hierarchy. Our results argue that dsh encodes a dosage sensitive component required for fz function and that it likely acts downstream of fz in the generation of tissue polarity. Our findings suggest that dsh may have a general role in signal transduction, perhaps as a component of a receptor complex.
果蝇中的组织极性基因对于协调表皮平面内的细胞极性是必需的。迄今为止的证据表明，这些基因可能编码一种新型信号转导途径的组分。其中三个基因，卷曲蛋白（fz）、散乱蛋白（dsh）和棘蛋白（pk）具有相似的组织极性表型，这表明它们在单一过程中共同发挥作用。已知dsh在果蝇的多种发育模式形成过程中作为无翅（wg）信号的介导因子发挥作用。在本研究中，我们利用一个fz转基因和一个低表达的fz等位基因作为遗传工具，试图在遗传层次中对这些基因进行排序。我们的结果表明，dsh编码fz功能所需的剂量敏感组分，并且它可能在组织极性产生过程中位于fz下游发挥作用。我们的发现表明，dsh可能在信号转导中具有普遍作用，也许作为受体复合物的一个组分。
