Pecorella I, McCartney A C, Lucas S, Michaels L, Ciardi A, Di Tondo U, Garner A
Department of Pathology, University College London Medical School, UK.
Histopathology. 1995 Nov;27(5):431-8. doi: 10.1111/j.1365-2559.1995.tb00306.x.
Review of a series of 98 eyes removed at autopsy from 86 AIDS patients identified 12 cases (14%) showing varying degrees of microscopic calcium oxalate deposition. The oxalate crystals were birefringent using polarisation microscopy and were stained histochemically by the silver nitrate-rubeanic acid method (Yasue), a stain considered to be specific for calcium oxalate. In two cases, the deposition was extensive and involved the surface of the ciliary processes, ciliary body and pars plana of the retina, the retinal and optic nerve blood vessel wall, a few retinal pigment cells, and the anterior inner sclera. A lesser degree of intraocular involvement was observed in the remaining 10 cases. In all but two eyes, where a peripheral active area of cytomegalovirus retinitis was present, no other significant microscopical abnormality was found. Clinically, these patients were asymptomatic. At autopsy, oxalate deposits were found in the kidney and/or thyroid in seven of the patients.
对86例艾滋病患者尸检摘除的98只眼睛进行的系列研究发现，12例（14%）出现不同程度的显微镜下草酸钙沉积。使用偏振显微镜观察，草酸晶体具有双折射性，并用硝酸银-赤藓酸法（安月法）进行组织化学染色，该染色法被认为对草酸钙具有特异性。在2例中，沉积广泛，累及睫状体突表面、睫状体、视网膜的扁平部、视网膜和视神经血管壁、一些视网膜色素细胞以及前内侧巩膜。其余10例中观察到的眼内受累程度较轻。除2只眼睛存在周边活动性巨细胞病毒性视网膜炎外，在所有其他眼睛中均未发现其他明显的显微镜下异常。临床上，这些患者无症状。尸检时，7例患者的肾脏和/或甲状腺中发现了草酸盐沉积。
