Mori S, Beppu T
Acta Pathol Jpn. 1983 Jul;33(4):661-9.
Various clinical and pathologic items were examined regarding renal oxalosis in 501 autopsy cases. The rubeanic acid method (Yasue) was applied to 501 kidney sections to demonstrate the presence of calcium oxalate crystals. The extent of renal oxalosis was determined by counting the black-stained crystals per 10 low-power field (1.3 cm2). Thus, severe oxalosis (more than 50 crystals) was observed in 38 cases; moderate oxalosis (between 10 and 50 crystals) in 19 cases; mild (fewer than 10 crystals) in 36 cases, and no deposition in 408 cases. Acute or chronic renal failure and xylitol infusion were found to be highly correlated to renal oxalosis. Cases with diabetes mellitus, with hepatocellular degeneration, or with glucose infusion, as well as neoplasms or some other alleged causes, were found to be primarily unrelated to renal oxalosis, even though the overlapping renal insufficiency, or xylitol infusion caused some of these items to appear related. In cases with xylitol infusion, the extent of renal oxalosis was shown to be dose-dependent: No severe or moderate oxalosis was observed in cases where the total dose of infusion was less than 100 g, while in cases over 500 g, 10/24, or 44 percent, showed severe oxalosis.
对501例尸检病例的肾草酸沉着症进行了各种临床和病理项目的检查。采用亚硫酸法（安江法）对501份肾脏切片进行检查，以证明草酸钙结晶的存在。通过计算每10个低倍视野（1.3平方厘米）中黑色染色的结晶数量来确定肾草酸沉着症的程度。因此，观察到38例严重草酸沉着症（超过50个结晶）；19例中度草酸沉着症（10至50个结晶）；36例轻度（少于10个结晶），408例无沉积。发现急性或慢性肾衰竭以及木糖醇输注与肾草酸沉着症高度相关。发现糖尿病、肝细胞变性、葡萄糖输注以及肿瘤或其他一些所谓病因的病例，即使重叠的肾功能不全或木糖醇输注导致其中一些病例看似相关，但主要与肾草酸沉着症无关。在木糖醇输注的病例中，肾草酸沉着症的程度显示为剂量依赖性：输注总量小于100克的病例未观察到严重或中度草酸沉着症，而超过500克的病例中，10/24或44%显示为严重草酸沉着症。
