Rogner U C, Wilke K, Steck E, Korn B, Poustka A
Deutsches Krebsforschungszentrum, Abteilung Molekulare Genomanalyse, Heidelberg, Germany.
Genomics. 1995 Oct 10;29(3):725-31. doi: 10.1006/geno.1995.9945.
The melanoma antigen gene (MAGE) family comprises 12 known genes, of which 6 are expressed in tumors. In the course of a systematic analysis of transcripts in Xq28, we have identified cDNAs related to different MAGE genes. Analysis of cell hybrids, ordered YACs, and cosmids showed that all MAGE genes are located in Xq28 and are clustered in three main intervals within 3.5 Mb. The six genes expressed in tumors are contained in the two intervals closest to the telomere and are highly homologous to each other. Analysis of different species suggests that human MAGE sequences are conserved in primates, but less well conserved in other vertebrate species.
黑色素瘤抗原基因（MAGE）家族由12个已知基因组成，其中6个在肿瘤中表达。在对Xq28转录本进行系统分析的过程中，我们鉴定出了与不同MAGE基因相关的cDNA。对细胞杂种、有序酵母人工染色体（YAC）和黏粒的分析表明，所有MAGE基因都位于Xq28，并且聚集在3.5兆碱基（Mb）范围内的三个主要区间。在肿瘤中表达的6个基因包含在最靠近端粒的两个区间内，并且彼此高度同源。对不同物种的分析表明，人类MAGE序列在灵长类动物中保守，但在其他脊椎动物物种中保守性较差。
