Watanabe T, Mukouyama Y, Rhodes M, Thomas M, Kume T, Oishi M
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Genomics. 1995 Oct 10;29(3):793-5. doi: 10.1006/geno.1995.9932.
It is now widely accepted that protein tyrosine phosphatases (PTPases) play important or even critical roles in cell growth, differentiation, and development. Our recent experiments suggested that specific PTPases, PTP beta 2 and PTP epsilon, are involved in the early molecular events for in vitro differentiation of mouse erythroleukemia (MEL) as well as embryonic carcinoma (F9) cells. Using mouse cDNA for PTP beta 2 and PTP epsilon, which we have cloned recently, we attempted to locate the genes to mouse chromosomes. Interspecific backcross analysis indicated that the gene for PTP beta 2, Ptprj, is located in the middle region of chromosome 2, and the gene for PTP epsilon, Ptpre, was mapped in the vicinity of the imprinted regions in the distal part of chromosome 7. Possible biological roles of these PTPases are discussed.
现在人们普遍认为，蛋白质酪氨酸磷酸酶（PTPases）在细胞生长、分化和发育中发挥着重要甚至关键的作用。我们最近的实验表明，特定的PTPases，即PTPβ2和PTPε，参与了小鼠红白血病（MEL）以及胚胎癌（F9）细胞体外分化的早期分子事件。利用我们最近克隆的小鼠PTPβ2和PTPε的cDNA，我们试图将这些基因定位到小鼠染色体上。种间回交分析表明，PTPβ2的基因Ptprj位于2号染色体的中部区域，而PTPε的基因Ptpre被定位在7号染色体远端印记区域附近。文中讨论了这些PTPases可能的生物学作用。
