Elson A, Kozak C A, Morton C C, Weremowicz S, Leder P
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Genomics. 1996 Feb 1;31(3):373-5. doi: 10.1006/geno.1996.0061.
We have mapped the mouse protein tyrosine phosphatase epsilon (PTP epsilon, gene symbol Ptpre) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses. The human PTP epsilon gene (gene symbol PTPRE) was mapped to chromosome 10q26 by fluorescence in situ hybridization. We have previously documented the existence of two isoforms of PTP epsilon--a transmembranal, receptor-type isoform and a shorter, cytoplasmic one. Both isoforms have been suggested to arise from a single gene through the use of alternative promoters and 5' exons. The identification of a single PTP epsilon locus in both organisms is consistent with this suggestion.
我们通过使用两组多位点遗传杂交的连锁分析，将小鼠蛋白酪氨酸磷酸酶ε（PTPε，基因符号Ptpre）基因定位到了7号染色体的远端区域。通过荧光原位杂交，将人类PTPε基因（基因符号PTPRE）定位到了10号染色体的q26区域。我们之前已经证明存在两种PTPε同工型——一种跨膜的受体型同工型和一种较短的胞质同工型。两种同工型都被认为是通过使用不同的启动子和5'外显子由单个基因产生的。在两种生物体中鉴定出单个PTPε基因座与这一推测是一致的。
