Swartz R P, Roecklein J A, Pierce P F, Yeager H
Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA.
Immunol Invest. 1995 Nov;24(6):987-98. doi: 10.3109/08820139509060723.
In patients with acquired immunodeficiency syndrome (AIDS), mycobacterial diseases are leading opportunistic infections. The reasons for the peculiar propensity for disseminated infection with Mycobacterium avium complex (MAC) remain unclear. We have previously examined, in detail, the ability of monocytes from healthy donors to take up and kill MAC under both nonopsonic and opsonic conditions. We have now evaluated the in vitro ability of peripheral blood monocytes from HIV(+) patients to take up and kill MAC organisms, and have discovered a reduced ability under both nonopsonic and opsonic conditions. This reduction is due to: 1) apparent defect(s) in the phagocytes themselves, and 2) substance(s) in the HIV(+) serum which actively suppresses phagocyte activity.
在获得性免疫缺陷综合征（艾滋病）患者中，分枝杆菌病是主要的机会性感染。鸟分枝杆菌复合体（MAC）播散性感染这种特殊倾向的原因尚不清楚。我们之前已经详细研究了健康供体的单核细胞在非调理和调理条件下摄取和杀死MAC的能力。我们现在评估了HIV（+）患者外周血单核细胞在体外摄取和杀死MAC菌的能力，发现在非调理和调理条件下该能力均降低。这种降低是由于：1）吞噬细胞本身明显存在缺陷，以及2）HIV（+）血清中的物质会积极抑制吞噬细胞活性。
