Buiatti E, Muñoz N, Kato I, Vivas J, Muggli R, Plummer M, Benz M, Franceschi S, Oliver W
Epidemiology Unit, Centro per lo Studio e la Prevenzione Oncologia, Florence, Italy.
Int J Cancer. 1996 Jan 26;65(3):317-22. doi: 10.1002/(SICI)1097-0215(19960126)65:3<317::AID-IJC7>3.0.CO;2-2.
Our objective was to identify the determinants of plasma levels of anti-oxidant vitamins which have been linked with decreased risk of cancer and other chronic diseases. Correlation analyses were performed between baseline plasma levels of ascorbic acid, alpha- and beta-carotenes, cryptoxanthin, lycopene and alpha- and gamma-tocopherols and baseline information on dietary and other demographic and life-style factors among 1,364 subjects 35-69 years of age, who are participants in a chemoprevention trial on pre-cancerous lesions of the stomach in Venezuela. Males had lower levels of ascorbic acid, alpha- and beta-carotene and cryptoxanthin and higher levels of alpha-tocopherol than females. This finding was confirmed in non-smokers and non-drinkers. In females, but not in males, age was positively associated with levels of ascorbic acid, cryptoxanthin, alpha- and beta-carotene and gamma-tocopherol. Male tobacco users had lower plasma levels of ascorbic acid, alpha- and beta-carotene and cryptoxanthin than nonusers, and regular alcohol drinkers had a decreased plasma levels of beta-carotene compared with non-drinkers. Female tobacco users had lower levels of ascorbic acid and cryptoxanthin than non-users, and regular alcohol drinkers had lower levels of ascorbic acid and lycopene than non-drinkers. Frequencies of consumption of fresh fruits, fruit juice, raw vegetables and plantains showed weak positive associations with plasma levels of several vitamins studied in both sexes. Sex, age in females, tobacco and alcohol use and dietary consumption affected plasma anti-oxidant vitamin levels in this population significantly. These factors may influence the effect of anti-oxidant treatment in intervention trials.
我们的目标是确定血浆中抗氧化维生素水平的决定因素，这些维生素与降低患癌风险及其他慢性疾病的风险有关。在1364名年龄在35至69岁的受试者中，对其抗坏血酸、α-和β-胡萝卜素、隐黄质、番茄红素以及α-和γ-生育酚的基线血浆水平与饮食及其他人口统计学和生活方式因素的基线信息进行了相关性分析，这些受试者参与了委内瑞拉一项关于胃癌前病变的化学预防试验。男性的抗坏血酸、α-和β-胡萝卜素以及隐黄质水平低于女性，而α-生育酚水平高于女性。这一发现在不吸烟和不饮酒者中得到了证实。在女性中，而非男性中，年龄与抗坏血酸、隐黄质、α-和β-胡萝卜素以及γ-生育酚水平呈正相关。男性吸烟者的抗坏血酸、α-和β-胡萝卜素以及隐黄质的血浆水平低于不吸烟者，经常饮酒者的β-胡萝卜素血浆水平低于不饮酒者。女性吸烟者的抗坏血酸和隐黄质水平低于不吸烟者，经常饮酒者的抗坏血酸和番茄红素水平低于不饮酒者。新鲜水果、果汁、生蔬菜和大蕉的食用频率与两性中所研究的几种维生素的血浆水平呈微弱的正相关。性别、女性年龄、烟草和酒精使用以及饮食消费对该人群血浆抗氧化维生素水平有显著影响。这些因素可能会影响干预试验中抗氧化治疗的效果。
