Gibbs J, Hughes S, Dunlop D, Singer R, Chang R W
Center for Health Services and Policy Research, Northwestern University, Evanston, IL 60208, USA.
J Am Geriatr Soc. 1996 Feb;44(2):126-32. doi: 10.1111/j.1532-5415.1996.tb02427.x.
To determine factors that predict change in walking velocity in older people using a multivariate model.
Longitudinal observational study.
A total of 588 persons older than age 60, including subjects residing in a continuing care retirement community (CCRC) (n = 248), and homebound (n = 79) and ambulatory (n = 261) subjects. Mean age at baseline = 77.
Independent variables included demographics, physician measures of lower-extremity joint impairment and other musculoskeletal and neurological variables, comorbidities derived from physical examination and chart abstract, self-assessed arthritis pain, depression, and anxiety. The major dependent variables were 2- and 4-year decline in walking velocity below a threshold associated with nursing home placement.
From baseline to Year 4, median walking velocity declined from 61.8 to 53.0 m/min, and the proportion of subjects above a threshold value of 11.5 m/min declined from 95.3% to 80.4%. Age, joint impairment, and weakness of quadriceps, measured at baseline, predicted 2-year and 4-year decline in walking velocity.
The findings indicate that joint impairment and quadriceps strength contribute significantly to crossing a clinically significant threshold in walking velocity among older people over time. Future research is needed to determine whether these risk factors can be modified through preventive interventions such as muscle-strengthening exercises and pain medication.
使用多变量模型确定预测老年人步行速度变化的因素。
纵向观察性研究。
共有588名60岁以上的人,包括居住在持续护理退休社区(CCRC)的受试者(n = 248)、居家老人(n = 79)和能行走的受试者(n = 261)。基线时的平均年龄为77岁。
自变量包括人口统计学特征、医生对下肢关节损伤的测量以及其他肌肉骨骼和神经学变量、体格检查和病历摘要得出的合并症、自我评估的关节炎疼痛、抑郁和焦虑。主要因变量是步行速度低于与养老院安置相关阈值的2年和4年下降情况。
从基线到第4年,步行速度中位数从61.8米/分钟降至53.0米/分钟,高于11.5米/分钟阈值的受试者比例从95.3%降至80.4%。基线时测量的年龄、关节损伤和股四头肌无力可预测步行速度的2年和4年下降情况。
研究结果表明,随着时间推移,关节损伤和股四头肌力量对老年人步行速度超过临床显著阈值有显著影响。需要进一步研究以确定这些风险因素是否可以通过诸如肌肉强化锻炼和止痛药物等预防性干预措施来改善。