Virgili A, Corazza M, Bianchi A, Mollica G, Califano A
Clinica Dermatologica, Università di Ferrara, Italy.
J Reprod Med. 1995 Sep;40(9):614-8.
To study the use of topical tretinoin for treating vulvar lichen sclerosus.
An open, uncontrolled clinical study on 22 patients affected by histologically confirmed vulvar lichen sclerosus. Topical 0.025% tretinoin was applied once a day, five days a week, for one year. Clinical and histologic parameters were evaluated before and after therapy, and statistical analysis was performed.
Symptoms, gross appearance and histopathologic features improved in a highly significant manner (P < .001). Cutaneous side effects were observed but rapidly disappeared, and no patient left the study for this reason. Maintenance of results was observed at the 4-13-month follow-up visits.
Topical tretinoin seems feasible for use in the topical treatment of vulvar lichen sclerosus.
研究外用维甲酸治疗外阴硬化性苔藓的效果。
对22例经组织学确诊为外阴硬化性苔藓的患者进行一项开放、非对照的临床研究。每天外用0.025%维甲酸，每周5天，持续1年。在治疗前后评估临床和组织学参数，并进行统计分析。
症状、外观和组织病理学特征均有极显著改善（P < .001）。观察到有皮肤副作用，但很快消失，且没有患者因此退出研究。在4至13个月的随访中观察到疗效得以维持。
外用维甲酸似乎可用于外阴硬化性苔藓的局部治疗。
