Novozhenov V G, Belonogov M A, Teselkin Iu O, Kolomoets N M, Prishchepov I A, Terent'ev V A, Kuleshova L S
Ter Arkh. 1996;68(3):58-62.
Lipid peroxidation (LPO) and antioxidant system (AOS) were examined in 40 inpatients with chronic obstructive bronchitis (COB) on conventional treatment. The above parameters were considered in relation to clinical picture. It is shown that inflammation in the bronchial tree is associated with AOS functional deterioration and marked LPO intensification. A correlation was established between LPO activity, concentration of alpha-tocopherol in red cell membrane and degree of bronchial obstruction as well as remission quality. Persistent high intensity of LPO is suggested as an underlying cause of the disease transition to chronic form and progression of bronchial obstruction. Basing on the above observations, the authors insist on antioxidants introduction in COB treatment.
对40例接受常规治疗的慢性阻塞性支气管炎（COB）住院患者的脂质过氧化（LPO）和抗氧化系统（AOS）进行了检测。上述参数与临床表现相关。结果表明，支气管树炎症与AOS功能恶化及显著的LPO强化有关。LPO活性、红细胞膜中α-生育酚浓度与支气管阻塞程度及缓解质量之间建立了相关性。LPO持续高强度被认为是疾病转变为慢性形式及支气管阻塞进展的潜在原因。基于上述观察结果，作者坚持在COB治疗中引入抗氧化剂。
