Burrows B, Knudson R J, Lebowitz M D
Am Rev Respir Dis. 1977 May;115(5):751-60. doi: 10.1164/arrd.1977.115.5.751.
This study of a general population sample reveals close relationships between histories of childhood respiratory disorders and pevalences of symptoms, obstructive airway diseases, and ventilatory impairment in 2,626 adults more than 20 years of age. Although a history of pediatric respiratory illness is associated with relatively mild impairment of ventilatory function in young adults, subjects with such a history shown an excessive decline in function with advancing years and with cigarette use. Because some of the data are retrospective and subject to the bias of preferential recall of childhood events, these observations cannot be regarded as definitive. However, present observations are compatible with the hypothesis that pediatric respiratory illness represents an important risk factor for the development of obstructive airway diseases in adult life. It is suggested that these childhood respiratory illnesses cause the adult lung to be unusually susceptible to the adverse effects of a variety of bronchial irritants and infectious agents.
这项针对普通人群样本的研究揭示了在2626名20岁以上成年人中，儿童期呼吸系统疾病史与症状患病率、阻塞性气道疾病及通气功能损害之间存在密切关系。尽管小儿呼吸系统疾病史与年轻成年人相对较轻的通气功能损害有关，但有此类病史的受试者随着年龄增长和吸烟，其功能会过度下降。由于部分数据是回顾性的，且存在对儿童期事件优先回忆的偏差，这些观察结果不能被视为定论。然而，目前的观察结果与小儿呼吸系统疾病是成年期阻塞性气道疾病发展的重要危险因素这一假设相符。有人认为，这些儿童期呼吸系统疾病会使成年肺对多种支气管刺激物和感染因子的不良影响异常敏感。
