Boxer M, Ellman L, Geller R, Wang C A
Arch Intern Med. 1977 May;137(5):588-93.
Although anemia has not been widely appreciated as a complication of primary hyperparathyroidism, 5.1% of the individuals with this disorder seen at the Massachusetts General Hospital since 1962 had a normochromic, normocytic anemia that could not be related to blood loss,a deficiency state, or uremia. The anemic group had more advanced bone disease and higher levels of serum calcium, alkaline phosphatase, and parathyroid hormone than the nonanemic group. Results of bone marrow biopsies performed in five patients showed variable degrees of myelofibrosis. However, none of the patients had hepatosplenomegaly, a myelophthisic peripheral blood smear, leukopenia, or thrombocytopenia. Removal of the abnormal parathyroid glands led to improvement or correction of the anemia.
尽管贫血作为原发性甲状旁腺功能亢进的一种并发症尚未得到广泛认识，但自1962年以来在马萨诸塞州总医院就诊的患有这种疾病的患者中，有5.1%患有正色素正细胞性贫血，这种贫血与失血、营养缺乏状态或尿毒症无关。贫血组比非贫血组有更严重的骨病，血清钙、碱性磷酸酶和甲状旁腺激素水平更高。对5例患者进行的骨髓活检结果显示有不同程度的骨髓纤维化。然而，所有患者均无肝脾肿大、骨髓消耗性外周血涂片、白细胞减少或血小板减少。切除异常的甲状旁腺可使贫血得到改善或纠正。
