Zaks N, Sukenik S, Alkan M, Flusser D, Neumann L, Buskila D
Department of Medicine, Soroka Medical Center, Ben-Gurion University, Beer Sheva, Israel.
Semin Arthritis Rheum. 1995 Oct;25(2):97-102. doi: 10.1016/s0049-0172(95)80022-0.
Rheumatological manifestations are frequently reported in patients with brucellosis. In a retrospective study of 90 patients diagnosed with brucellosis over a period of 18 years, 83 (92%) patients were Bedouins, 55 of whom (61%) reported ingestion of unpasteurized goat milk and goat milk products. The male/female ratio was 1:1, and the adult to child ratio was 3:2. The mean age of the patients was 25 years (range, 1-72 years). Rheumatological manifestations (myalgia, arthralgia, and arthritis) were reported in more than half of the patients. These manifestations started on days 3 and 4 of the disease and were mild to moderate in severity. Myalagia was evident in 49 (54%) patients and was more common in adults than in children (67% versus 37%; P < .01) and in men (67%) than in women (42%; P < .01). Arthralgia was the most common musculoskeletal manifestation, found in 55 (61%) patients, and occurred more often in children than in adults (74% versus 52%; P < .05). Arthritis was detected in 37 (41%) patients. The hip and knee joints were the most common sites of arthritis (31% each) followed by sacroiliac involvement (17%) and shoulder or spine involvement (5% each). Arthritis was also more common in children (63% versus 29%; P < .01). The prevalence of arthritis was similar in men and women. Cure was achieved in all patients after antibiotic therapy.
布鲁氏菌病患者常出现风湿性表现。一项对18年间确诊的90例布鲁氏菌病患者的回顾性研究显示，83例（92%）患者为贝都因人，其中55例（61%）报告摄入过未经巴氏消毒的山羊奶及山羊奶制品。男女比例为1:1，成人与儿童比例为3:2。患者的平均年龄为25岁（范围1 - 72岁）。超过半数患者报告有风湿性表现（肌痛、关节痛和关节炎）。这些表现在疾病第3天和第4天开始出现，严重程度为轻至中度。49例（54%）患者有明显肌痛，在成人中比儿童更常见（67%对37%；P <.01），在男性中比女性更常见（67%对42%；P <.01）。关节痛是最常见的肌肉骨骼表现，见于55例（61%）患者，在儿童中比成人更常出现（74%对52%；P <.05）。37例（41%）患者检测出关节炎。髋和膝关节是最常见的关节炎部位（各占31%），其次是骶髂关节受累（17%）以及肩部或脊柱受累（各占5%）。关节炎在儿童中也更常见（63%对29%；P <.01）。男性和女性的关节炎患病率相似。所有患者经抗生素治疗后均治愈。
