Biagioni P A, Lamey P J
School of Clinical Dentistry, Queen's University of Belfast Royal Victoria Hospital, UK.
Acta Derm Venereol. 1995 Jul;75(4):264-8. doi: 10.2340/0001555575264268.
The purpose of this study was to ascertain the applicability of infrared thermography to study the natural history of herpes labialis lesions. Since thermography is capable of detecting changes not visible to the naked eye, then it may be of value in complementing clinical examination of the various stages of herpes labialis. In addition, thermographic imaging is quantitative and therefore allows for an accurate assessment of temperature changes accompanying the disease process, both within patients and between patients. Ten female patients suffering from herpes labialis were studies (mean age 25 +/- 5 years). In all cases herpes simplex virus Type 1 was isolated by the HEP-2 technique. No treatment was instituted and patients were clinically assessed and thermographically imaged daily from the prodromal phase through to resolution. A marked temperature increase (1 degree C minimum) was observed within hours of the prodromal phase and maintained until day 4. As the lesions progressed to vesicle formation, the central area of the vesicle was noted to be cooler due to the insulating effect of the fluid. Even by day 6 a significant 0.5 degree C temperature increase over background was present at the involved site and this returned to normal within 8 to 10 days. The area of thermographic involvement was three to four times larger than the clinical area of involvement (60-100 mm2 versus 20-25 mm2). To assess reproducibility, we also studied patients through two additional untreated herpes labialis episodes. The prodromal phase was reproducible thermographically and characterized by a temperature increase of 1.42 degrees C +/- 0.2 degrees C. Thermographic imaging may represent a new approach to quantifying disease activity in herpes labialis, particularly in the subclinical prodromal stage.
本研究的目的是确定红外热成像技术在研究唇疱疹病变自然史方面的适用性。由于热成像能够检测肉眼不可见的变化，因此它可能有助于补充唇疱疹各阶段的临床检查。此外，热成像具有定量性，因此能够准确评估疾病过程中患者体内以及患者之间伴随的温度变化。对10名患有唇疱疹的女性患者进行了研究（平均年龄25±5岁）。所有病例均通过HEP - 2技术分离出1型单纯疱疹病毒。未进行任何治疗，从前驱期到痊愈，每天对患者进行临床评估和热成像检查。在前驱期数小时内观察到明显的温度升高（至少1摄氏度），并持续到第4天。随着病变发展为水疱形成，由于疱内液体的隔热作用，水疱中心区域温度较低。甚至到第6天，受累部位的温度仍比基线显著升高0.5摄氏度，并在8至10天内恢复正常。热成像显示的受累面积比临床受累面积大3至4倍（60 - 100平方毫米对20 - 25平方毫米）。为评估可重复性，我们还对患者另外两次未经治疗的唇疱疹发作进行了研究。前驱期在热成像上具有可重复性，其特征是温度升高1.42摄氏度±0.2摄氏度。热成像可能是一种量化唇疱疹疾病活动的新方法，特别是在亚临床前驱期。
