Rytel M W, Niebojewski R A, Aguilar-Torres F G, Russell T J
Am J Med Sci. 1978 Nov-Dec;276(3):319-23. doi: 10.1097/00000441-197811000-00009.
The purpose of this study was to provide additional information on the clinical course and viral replication kinetics of herpes simplex virus (HSV) in recurrent herpes labialis. Data were obtained on 20 subjects who were followed for five days from the first day of the lesion. HSV was isolated in 17 subjects (85%); 75% were positive on day 1 of the lesion. Median HSV titer on day 1 was 1.7 x 10(3)/0.2ml. Isolation rates and titers dropped sharply and virus could no longer be detected by day 4. The clinical course both in terms of the frequency and the severity of the symptoms paralleled the kinetics of viral replication. Thermography delineated location of subsequent lesions in three early symptomatic patients who were studied at the time when no visible lesions were observed. These data are felt to provide useful background information for future studies on the efficacy of topical antiviral agents.
本研究的目的是提供关于复发性唇疱疹中单纯疱疹病毒（HSV）临床病程及病毒复制动力学的更多信息。对20名受试者从病损第一天起进行了为期五天的随访，并获取了相关数据。17名受试者（85%）分离出了HSV；病损第一天75%呈阳性。病损第一天HSV滴度中位数为1.7×10³/0.2ml。分离率和滴度急剧下降，到第4天就再也检测不到病毒了。症状的频率和严重程度方面的临床病程与病毒复制动力学情况相似。热成像描绘了三名早期有症状患者在未观察到可见病损时后续病损的位置。这些数据被认为可为今后局部抗病毒药物疗效研究提供有用的背景信息。
