Lauerma A I, Aioi A, Maibach H I
Department of Dermatology, University of California, San Francisco 94143-0989, USA.
Acta Derm Venereol. 1995 Jul;75(4):272-5. doi: 10.2340/0001555575272275.
Cis-urocanic acid, converted from trans-urocanic acid in stratum corneum by ultraviolet B irradiation, has been shown to impair contact hypersensitivity induction. To study whether topical cis-urocanic acid also alters contact hypersensitivity elicitation, as well as immediate hypersensitivity and acute irritation, we treated mice with 1% topical cis-urocanic acid or vehicle prior to induction or elicitation of hypersensitivity to contact allergen oxazolone or respiratory allergen trimellitic anhydride or prior to acute irritation from croton oil. Topical cis-urocanic acid suppressed both induction and elicitation of contact hypersensitivity to oxazolone. However, no effect by cis-urocanic acid on induction or elicitation of trimellitic anhydride allergy or croton oil irritation was seen. The possible efficacy of topical cis-urocanic acid as a treatment of inflammatory skin diseases responsive to ultraviolet B irradiation may be worthwhile to investigate.
顺式尿刊酸可通过紫外线B照射在角质层中由反式尿刊酸转化而来，已被证明会损害接触性超敏反应的诱导。为了研究局部应用顺式尿刊酸是否也会改变接触性超敏反应的激发，以及速发型超敏反应和急性刺激反应，我们在对接触性变应原恶唑酮或呼吸道变应原偏苯三酸酐的超敏反应诱导或激发之前，或在巴豆油引起急性刺激之前，用1%的局部顺式尿刊酸或赋形剂处理小鼠。局部应用顺式尿刊酸抑制了对恶唑酮的接触性超敏反应的诱导和激发。然而，未观察到顺式尿刊酸对偏苯三酸酐过敏的诱导或激发或巴豆油刺激有影响。局部应用顺式尿刊酸作为治疗对紫外线B照射有反应的炎症性皮肤病的可能疗效值得研究。
