Kushlinskiĭ N E, Solov'ev Iu N
Arkh Patol. 1995 Sep-Oct;57(5):25-30.
The content of prostaglandins E (PGE) is studied in osteogenic sarcomas from 191 patients. The level of PGE after a neo-adjuvant therapy of osteogenic sarcoma depends upon the individual susceptibility to the drug. Inverse correlation is found between the PGE content in the tumor and the degree of therapeutic pathomorphosis when adriamycin and methotrexate are used before the operation. Single transfusion of the allogenic bone-marrow suspension results in a considerable decrease of the PGE level in the osteogenic sarcoma. Possible mechanisms of action of different therapeutical methods on the PGE level as well as use of the drugs influencing arachidonic acid metabolism in the tumor are discussed.
对191例骨肉瘤患者的前列腺素E（PGE）含量进行了研究。骨肉瘤新辅助治疗后的PGE水平取决于个体对该药物的敏感性。术前使用阿霉素和甲氨蝶呤时，肿瘤中PGE含量与治疗性病理形态改变程度呈负相关。单次输注同种异体骨髓悬液可使骨肉瘤中PGE水平显著降低。讨论了不同治疗方法对PGE水平的可能作用机制以及影响肿瘤中花生四烯酸代谢的药物的应用。
