Kushlinskiĭ N E, Bassalyk L S, Liakina L T, Solov'ev Iu N, Pashkov Iu V, Amiraslanov A T, Siniukov P A, Valenteĭ L V, Fedenko A N, Abaev V M
Vopr Onkol. 1992;38(8):929-35.
Levels of prostaglandin E (PGE), prostaglandin F2 alpha, prostacyclin A2, thromboxan B2 and leucotriene B4 assayed radioimmunologically were compared in 42 samples of osteogenic sarcoma and 22 samples of benign tumors and tumor-like lesions from children at the pubertal period. In osteogenic sarcoma samples, PGE and prostaglandin F2 alpha levels were higher than those of thromboxan B2, prostacyclin A2 and leucotriene B4. Osteogenic sarcoma revealed higher levels of the eicosanoids as compared to benign tumors and tumor-like lesions of the bone. An inverse correlation was established between PGE level and time of dissemination of osteogenic sarcoma. The role of eicosanoids in the pathogenesis of growth and dissemination of osteogenic sarcoma is discussed. The use of non-steroid anti-inflammatory drugs in complex treatment of osteogenic sarcoma of children at the pubertal period is suggested.
采用放射免疫法对42例青春期儿童骨肉瘤样本和22例良性肿瘤及肿瘤样病变样本中的前列腺素E（PGE）、前列腺素F2α、前列环素A2、血栓素B2和白三烯B4水平进行了比较。在骨肉瘤样本中，PGE和前列腺素F2α水平高于血栓素B2、前列环素A2和白三烯B4。与骨的良性肿瘤和肿瘤样病变相比，骨肉瘤显示出更高水平的类花生酸。PGE水平与骨肉瘤的扩散时间之间建立了负相关。讨论了类花生酸在骨肉瘤生长和扩散发病机制中的作用。建议在青春期儿童骨肉瘤的综合治疗中使用非甾体抗炎药。
