Orr P H, Dong V, Schroeder M L, Ogborn M R
Department of Community Health Sciences, University of Manitoba, Canada.
Pediatr Nephrol. 1995 Oct;9(5):612-3. doi: 10.1007/BF00860953.
P1 blood group positivity has been postulated as a host factor which may provide protection against the development of post-enteropathic hemolytic uremic syndrome (HUS). In this study, blood group status in 20 Inuit survivors of Escherichia coli O157:H7-associated HUS was compared with age- and sex-matched controls from the same community who had experienced uncomplicated diarrheal illness due to the same pathogen. Of 20 HUS survivors, 6 were P1 antigen positive compared with 8 of the 20 controls (P = 0.7). We conclude that P1 antigen positivity was not protective against HUS in this population. Further studies of this condition to clarify the role of host factors in verotoxin-induced endothelial damage are indicated.
P1血型阳性被认为是一种宿主因素，可能对肠病后溶血性尿毒症综合征（HUS）的发展具有保护作用。在本研究中，将20名因大肠杆菌O157:H7相关HUS幸存的因纽特人与来自同一社区、年龄和性别匹配、因相同病原体经历过非复杂性腹泻疾病的对照者的血型状况进行了比较。在20名HUS幸存者中，6名P1抗原呈阳性，而20名对照者中有8名呈阳性（P = 0.7）。我们得出结论，在该人群中，P1抗原阳性对HUS没有保护作用。有必要对这种情况进行进一步研究，以阐明宿主因素在志贺毒素诱导的内皮损伤中的作用。
