van Reekum R, Links P S, Finlayson M A, Boyle M, Boiago I, Ostrander L A, Moustacalis E
Department of Psychiatry, University of Toronto, Ontario, Canada.
J Psychiatry Neurosci. 1996 Jan;21(1):13-20.
Previous research has tentatively identified a large subgroup of patients with borderline personality disorder (BPD) with histories of developmental or acquired brain insults. Similarly, these studies have demonstrated a possible biological correlation between the severity of BPD and the number of previous brain insults. The possibility of frontal system cognitive dysfunction in BPD has been raised. This single-blind, case-control study of BPD showed that 13 of 24 subjects with BPD had suffered a brain insult. Correlations between neurodevelopmental/acquired brain injury score and the diagnostic interview for borderline (DIB) score (r = 0.47), and between frontal system cognitive functioning and DIB score (r = -0.37) were seen. Neurocognitive testing and comparison with a cohort of subjects with traumatic brain injury (TBI) showed a pattern of similar cognitive functioning between the 2 groups, with the only differences on individual tests being in the direction of worse functioning in the group with BPD on 2 tasks. These results support the hypotheses described above. The main limitation reflects the low numbers of subjects.
先前的研究初步确定了一大亚组边缘型人格障碍（BPD）患者，他们有发育性或后天性脑损伤史。同样，这些研究表明BPD的严重程度与既往脑损伤的次数之间可能存在生物学关联。BPD患者存在额叶系统认知功能障碍的可能性已被提出。这项针对BPD的单盲病例对照研究表明，24名BPD受试者中有13人曾遭受脑损伤。观察到神经发育/后天性脑损伤评分与边缘型人格障碍诊断访谈（DIB）评分之间的相关性（r = 0.47），以及额叶系统认知功能与DIB评分之间的相关性（r = -0.37）。神经认知测试以及与一组创伤性脑损伤（TBI）受试者的比较显示，两组之间存在相似的认知功能模式，个体测试中唯一的差异在于，在两项任务上，BPD组的功能表现更差。这些结果支持上述假设。主要局限性在于受试者数量较少。
