Ruocco Anthony C
Department of Psychology, Drexel University, 245 N. 15th Street, Mail Stop 626, Philadelphia, PA 19102-1192, USA.
Psychiatry Res. 2005 Dec 15;137(3):191-202. doi: 10.1016/j.psychres.2005.07.004. Epub 2005 Nov 17.
The neuropsychological profile of borderline personality disorder (BPD) is unclear. Past investigations have produced seemingly inconsistent results concerning precisely what neuropsychological deficits characterize the patient with BPD. A meta-analysis of 10 studies was conducted comparing BPD and healthy comparison groups on selected neuropsychological measures comprising six domains of functioning: attention, cognitive flexibility, learning and memory, planning, speeded processing, and visuospatial abilities. BPD participants performed more poorly than controls across all neuropsychological domains, with mean effect sizes (Cohen's d) ranging from -0.29 for cognitive flexibility to -1.43 for planning. The results suggest that persons with BPD perform more poorly than healthy comparison groups in multiple neurocognitive domains and that these deficits may be more strongly lateralized to the right hemisphere. Although neuropsychological testing appears to be sensitive to the neurocognitive deficits of BPD, the clinical utility of these results is limited. Implications of these findings for future neurocognitive investigations of BPD are discussed.
边缘型人格障碍（BPD）的神经心理学特征尚不清楚。过去的研究在究竟哪些神经心理学缺陷是BPD患者的特征方面产生了看似不一致的结果。对10项研究进行了荟萃分析，在选定的包括六个功能领域的神经心理学测量指标上比较了BPD组和健康对照组：注意力、认知灵活性、学习和记忆、计划、快速处理以及视觉空间能力。BPD参与者在所有神经心理学领域的表现均比对照组差，平均效应大小（科恩d值）范围从认知灵活性的-0.29到计划的-1.43。结果表明，BPD患者在多个神经认知领域的表现比健康对照组差，并且这些缺陷可能更强烈地偏向右侧半球。尽管神经心理学测试似乎对BPD的神经认知缺陷敏感，但这些结果的临床效用有限。讨论了这些发现对未来BPD神经认知研究的意义。
