Cassidy W M, Mahoney F J
Louisiana State University School of Medicine, Earl K. Long Medical Center, Baton Rouge, Louisiana, USA.
J Adolesc Health. 1995 Oct;17(4):244-7. doi: 10.1016/1054-139X(95)00132-C.
To determine the effectiveness of using a middle school for hepatitis B vaccination of adolescents.
An immunization program was designed to educate parents and students about hepatitis B virus (HBV) infection and hepatitis B vaccination using science class presentations and mailings. Students were given at each visit and on vaccination series completion. Costs were calculated and divided by the number of students completing the series to obtain per student cost.
Of the 654 students, 519 (79%) received at least one dose of hepatitis B vaccine, 497 (76%) two doses, and 425 (65%) three doses. Student participation did not vary by grade level, gender, or income. Per student vaccination cost was $77.23 for those receiving three doses of hepatitis B vaccine and $66.04 when those receiving at least two doses were included. Of 103 students with postvaccination serologic testing, three had evidence of previous hepatitis B virus infection, four had no evidence of vaccine induced immunity, and 96 (96% of susceptible students) developed protective levels of antibodies against hepatitis B surface antigen. The geometric mean antibody titer among persons responding to vaccination was 661 mIU.
Hepatitis B vaccination of adolescents can be successfully integrated into a middle school setting.
确定利用中学开展青少年乙型肝炎疫苗接种的有效性。
设计了一项免疫计划，通过科学课演示和邮寄资料，向家长和学生传授乙型肝炎病毒（HBV）感染及乙型肝炎疫苗接种的相关知识。每次就诊时及完成疫苗接种系列后均对学生进行评估。计算成本，并除以完成该系列接种的学生人数，得出每名学生的成本。
在654名学生中，519名（79%）至少接种了一剂乙型肝炎疫苗，497名（76%）接种了两剂，425名（65%）接种了三剂。学生参与度在年级、性别或收入方面并无差异。接种三剂乙型肝炎疫苗的学生每人的接种成本为77.23美元，若将至少接种两剂的学生纳入计算，则每人成本为66.04美元。在103名接种后进行血清学检测的学生中，3名有既往乙型肝炎病毒感染证据，4名无疫苗诱导免疫证据，96名（96%的易感学生）产生了针对乙型肝炎表面抗原的保护性抗体水平。接种疫苗后产生反应的人群中，抗体几何平均滴度为661 mIU。
青少年乙型肝炎疫苗接种可成功纳入中学环境。
