Javed T, Dombrink-Kurtzman M A, Richard J L, Bennett G A, Côté L M, Buck W B
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
J Vet Diagn Invest. 1995 Oct;7(4):520-6. doi: 10.1177/104063879500700417.
Two hundred twenty-eight male broiler chicks (Columbia x New Hampshire) were given feed amended with autoclaved culture material of Fusarium proliferatum containing fumonisin B1 (FB1) at 61, 193, and 546 ppm, fumonisin B2 (FB2) at 14, 38, and 98 ppm, and moniliformin at 66, 193, and 367 ppm in 3 separate feeding trials (amounts of toxin in each trial, respectively). Birds were started on amended rations at days 1, 7, and 21 and continuing for 14 days. Of serum chemistry parameters, only glucose was significantly decreased. Significant increases were noted in serum cholesterol, sodium, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and gamma-glutamyl transferase. Of the hematologic parameters, significant decreases were noted in red blood cell counts, hemoglobin, packed cell volume, and white blood cell counts. Immunologic changes included impaired anti-Newcastle disease antibody hemagglutination inhibition titers associated with relative decreases in total serum globulins and increases in albumin/globulin ratios. The changes were noted in all treatment groups when compared to controls.
在三项独立的饲养试验中，给228只雄性肉鸡雏鸡（哥伦比亚×新罕布什尔）饲喂添加了含伏马菌素B1（FB1）分别为61、193和546 ppm、伏马菌素B2（FB2）分别为14、38和98 ppm以及串珠镰刀菌素分别为66、193和367 ppm的高压灭菌的层出镰刀菌培养物的饲料（每次试验中每种毒素的含量）。雏鸡在第1、7和21天开始饲喂添加饲料，并持续14天。在血清化学参数中，只有葡萄糖显著降低。血清胆固醇、钠、碱性磷酸酶、天冬氨酸转氨酶、丙氨酸转氨酶、乳酸脱氢酶和γ-谷氨酰转移酶显著升高。在血液学参数中，红细胞计数、血红蛋白、血细胞比容和白细胞计数显著降低。免疫变化包括与血清总球蛋白相对降低和白蛋白/球蛋白比值升高相关的抗新城疫抗体血凝抑制效价受损。与对照组相比，所有处理组均出现了这些变化。
