Espada Y, Ruiz de Gopegui R, Cuadradas C, Cabañes F J
Faculty of Veterinary Science, Universidad Autónoma Barcelona, Bellaterra, Spain.
Avian Dis. 1994 Jul-Sep;38(3):454-60.
The effects of fumonisin B1 (FB1) intoxication in chickens was evaluated in three experiments. Two-day-old broiler chicks were fed a diet containing 10 mg pure FB1/kg feed for 6 days; some chicks were necropsied at this time, and others were allowed to recover for 5 weeks before necropsy. In two other experiments, 2-day-old chicks were fed a broiler starter ration prepared with Fusarium moniliforme culture material containing FB1; one group received 30 mg/kg for 2 weeks, and another received 300 mg FB1/kg for 8 days. Compared with controls, intoxicated chicks exhibited diarrhea; decreases in body weight and in liver, spleen, and bursa absolute weights; a hepatic relative weight increase; and spleen relative weight decrease. Triglycerides, uric acid levels, and alkaline phosphatase activity decreased, and gamma glutamyl transferase, aspartate aminotransferase, lactic dehydrogenase, creatine kinase, and cholesterol increased. The results indicate that low doses of pure FB1 (10 mg/kg) and FB1 from Fusarium moniliforme culture material (30 mg/kg) are toxic to young chicks.
通过三项实验评估了伏马菌素B1（FB1）对鸡的中毒影响。给2日龄的肉鸡雏鸡饲喂含有10毫克纯FB1/千克饲料的日粮，持续6天；此时对部分雏鸡进行剖检，其他雏鸡在剖检前恢复5周。在另外两项实验中，给2日龄雏鸡饲喂用含有FB1的串珠镰刀菌培养物制备的肉鸡育雏日粮；一组接受30毫克/千克，持续2周，另一组接受300毫克FB1/千克，持续8天。与对照组相比，中毒雏鸡出现腹泻；体重、肝脏、脾脏和法氏囊绝对重量下降；肝脏相对重量增加；脾脏相对重量下降。甘油三酯、尿酸水平和碱性磷酸酶活性降低，γ-谷氨酰转移酶、天冬氨酸氨基转移酶、乳酸脱氢酶、肌酸激酶和胆固醇增加。结果表明，低剂量的纯FB1（10毫克/千克）和来自串珠镰刀菌培养物的FB1（30毫克/千克）对雏鸡有毒。
