Noble R L
Cancer Res. 1977 Jun;37(6):1929-33.
The low spontaneous incidence of grossly recognizable adenocarcinomas of the dorsal lobe of the prostate in Nb rats over 13 months old (0.45%) was increased to 18.38% in 130 rats by prolonged treatment with pellets of suitable sex hormones. Although testosterone propionate alone was effective, if the testosterone propionate was combined with treatment by estrone carcinomas of the prostate occurred after a shorter interval. Tumors tended to metastasize and transplanted readily, and all were autonomous, with a single exception that exhibited the growth pattern of a typical estrogen-dependent tumor.
13个月以上的Nb大鼠前列腺背叶明显可辨的腺癌自发发生率较低（0.45%），通过用合适的性激素丸粒进行长期治疗，130只大鼠的发生率增加到了18.38%。虽然单独使用丙酸睾酮是有效的，但如果将丙酸睾酮与雌酮联合治疗，前列腺癌会在更短的间隔后发生。肿瘤易于转移且易于移植，所有肿瘤都是自主性的，只有一个例外表现出典型的雌激素依赖性肿瘤的生长模式。
