Donis R O
Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, USA.
Vet Clin North Am Food Anim Pract. 1995 Nov;11(3):393-423. doi: 10.1016/s0749-0720(15)30459-x.
The contributions of pestivirus molecular biology research to our understanding of Bovine Viral Diarrhea Virus (BVDV) biology and disease have been remarkable. Completion of nucleotide sequence information for genomes of NCP and CP-BVDV isolates was an important milestone. Subsequent work on the protein map of BVDV and polyprotein processing pathways paved the way for the interpretation of many other virologic and immunologic studies. Discovery of a correlation between genotype II and virulence (hemorrhagic syndrome) will help to clarify previously controversial data and to improve disease control. Description of multiple pathways of p80 expression in CP-BVDV offered insight into the pathogenesis of mucosal disease. Identification of gp53/ E2 as the target of neutralizing antibodies and source of antigenic hypervariability helped us to understand immunity to BVDV. Collectively, the advances described contribute to the implementation of improved diagnostic and control strategies to reduce losses inflicted by the bovine pestivirus.
瘟病毒分子生物学研究对我们理解牛病毒性腹泻病毒（BVDV）生物学特性及疾病的贡献显著。非细胞病变型（NCP）和细胞病变型（CP）BVDV分离株基因组核苷酸序列信息的完成是一个重要的里程碑。随后关于BVDV蛋白质图谱和多蛋白加工途径的研究为许多其他病毒学和免疫学研究的解读铺平了道路。II型基因型与毒力（出血综合征）之间相关性的发现将有助于澄清以前有争议的数据并改善疾病控制。对CP-BVDV中p80表达多种途径的描述为黏膜病发病机制提供了见解。将糖蛋白53/E2（gp53/E2）鉴定为中和抗体的靶标和抗原高变异性的来源有助于我们理解对BVDV的免疫。总体而言，上述进展有助于实施改进的诊断和控制策略，以减少牛瘟病毒造成的损失。
