Agius A M, Wake M, Pahor A L, Smallman L A
Department of Otolaryngology, City Hospital NHS Trust, Birmingham, UK.
Clin Otolaryngol Allied Sci. 1995 Oct;20(5):470-4. doi: 10.1111/j.1365-2273.1995.tb00084.x.
The middle ear mucociliary system has been shown to have an important function in the clearance of effusions. Little is known, however, about its role in chronic suppurative otitis media (CSOM). The ciliary beat frequencies of middle ear mucosal biopsies and nasal brushings of 27 patients with CSOM were analysed using a computerized photometric technique. The ciliary beat frequency in the middle ear mucosa was significantly less than that in nasal mucosa. Frequency in ears of smoking patients was significantly lower compared with non-smoking patients. Nasal brushings were taken from 27 otherwise healthy age and sex-matched non-smoking controls and the ciliary beat frequency was very similar to nasal samples from patients with CSOM. Ear controls were obtained from otosclerotic patients undergoing tympanotomy and the beat frequency was significantly higher than in the ear of patients with CSOM. It is concluded that middle ear ciliary function is significantly reduced in CSOM, particularly in patients who smoke.
中耳黏液纤毛系统在积液清除中已显示出具有重要功能。然而，对于其在慢性化脓性中耳炎（CSOM）中的作用却知之甚少。采用计算机光度技术分析了27例CSOM患者的中耳黏膜活检组织和鼻刷检物的纤毛摆动频率。中耳黏膜的纤毛摆动频率显著低于鼻黏膜。与不吸烟患者相比，吸烟患者耳部的纤毛摆动频率明显更低。从27名年龄和性别匹配的其他方面健康的不吸烟对照者中获取鼻刷检物，其纤毛摆动频率与CSOM患者的鼻样本非常相似。耳部对照取自接受鼓室切开术的耳硬化症患者，其纤毛摆动频率明显高于CSOM患者的耳部。得出的结论是，CSOM患者的中耳纤毛功能显著降低，尤其是吸烟患者。
