Lu J, Tian J, Zhang J
Department of Nephrology, First Air Force Hospital in Shanghai.
Zhonghua Nei Ke Za Zhi. 1995 Jun;34(6):371-3.
A total of 114 samples of serum soluble interleukin-2 receptor levels (sIL-2R) were dynamicly measured with enzyme linked immunosorbent assay (ELISA) in 24 patients with renal allografts. Serum sIL-2R levels in patients with uremia were evidently higher than those in normal control group and it was markedly reduced after recovery of allograft function. The elevation of serum sIL-2R was evident in acute rejection episode and was found as early as 3-8 days before elevation of serum creatinine. Patients with cyclosporine nephrotoxicity, acute tubular necrosis and stable renal function without rejection did not have a comparable rise in sIL-2R. These data show that the level of serum sIL-2R is regarded as an important parameter for the early diagnosis of acute rejection episode. It was noted that pre-operation level of serum sIL-2R in uremic patients may foretell the possible occurrence of acute rejection episode and the prognosis after renal transplantation. It was specially emphasized that serial assay with change of sIL-2R level and comparison of the level with that before transplantation are more important than a single serum sIL-2R level assay for the early diagnosis and differential diagnosis of acute rejection.
采用酶联免疫吸附测定法（ELISA）动态检测了24例同种异体肾移植患者的114份血清可溶性白细胞介素-2受体水平（sIL-2R）。尿毒症患者血清sIL-2R水平明显高于正常对照组，移植肾功能恢复后显著降低。急性排斥反应发作时血清sIL-2R升高明显，且早在血清肌酐升高前3 - 8天就已出现。环孢素肾毒性、急性肾小管坏死以及肾功能稳定无排斥反应的患者，其sIL-2R无类似升高。这些数据表明，血清sIL-2R水平可作为急性排斥反应发作早期诊断的重要参数。值得注意的是，尿毒症患者术前血清sIL-2R水平可能预示急性排斥反应发作的可能性及肾移植后的预后。特别强调的是，对于急性排斥反应的早期诊断和鉴别诊断，连续检测sIL-2R水平的变化并与移植前水平进行比较，比单次检测血清sIL-2R水平更为重要。
