Suzuki Y
Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan.
Hokkaido Igaku Zasshi. 1995 Nov;70(6):847-59.
The changes of torsional eye movements after the riMLF (rostral interstitial nucleus of the medial longitudinal fasciculus) lesions with kainic acid have been investigated in three rhesus monkeys. After unilateral lesion, torsional rapid eye movements were lost to ipsi-torsional (extorsion of the ipsilateral eye and intorsion of the contralateral eye) side only, while vertical movements were still possible. All monkeys showed counter-torsional (intorsion of the ipsilateral eye and extorsion of the contralateral eye) shifts and thickening of Listing's plane. These changes of Listing's plane were always less in the dark. After the second contralateral lesions, all torsional and vertical rapid eye movements were permanently lost. Listing's plane moved to the opposite torsional direction beyond zero. On-average, the residual torsional shift in the light was only 17.4% of the shift in the light after the first lesion. Furthermore, the thickness of Listing's plane decreased to the level of the pre-lesion state. These results suggest that burst neurons in the riMLF are essential to generate vertical and/or torsional rapid eye movements and symmetrical activity of them is necessary to keep Listing's plane around zero and to minimize its variability. Yet, after bilateral lesions, Listing's law is still preserved, suggesting its neural implementation in parallel to or downstream of the riMLF.
在三只恒河猴身上研究了用 kainic 酸损伤内侧纵束嘴侧间质核（riMLF）后扭转性眼球运动的变化。单侧损伤后，扭转性快速眼球运动仅在同侧扭转（同侧眼外旋和对侧眼内旋）侧消失，而垂直运动仍有可能。所有猴子都出现了反向扭转（同侧眼内旋和对侧眼外旋）移位以及 Listing 平面增厚。这些 Listing 平面的变化在黑暗中总是较小。在对侧第二次损伤后，所有扭转性和垂直性快速眼球运动永久消失。Listing 平面向相反的扭转方向移动超过零。平均而言，光照下的残余扭转移位仅为首次损伤后光照下移位的 17.4%。此外，Listing 平面的厚度降至损伤前状态水平。这些结果表明，riMLF 中的爆发神经元对于产生垂直和/或扭转性快速眼球运动至关重要，并且它们的对称活动对于使 Listing 平面保持在零附近并最小化其变异性是必要的。然而，双侧损伤后，Listing 定律仍然保留，这表明它在 riMLF 平行或下游的神经实现。
