Suzuki Y, Büttner-Ennever J A, Straumann D, Hepp K, Hess B J, Henn V
Physiology Department, Hokkaido University School of Medicine, Sapporo, Japan.
Exp Brain Res. 1995;106(2):215-32. doi: 10.1007/BF00241117.
The rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) contains burst neurons whose activity precedes rapid eye movements with a vertical and/or torsional component. To ascertain their causal role in the generation of conjugate eye movements, we placed uni- and bilateral kainic acid lesions in that region. Unilateral inactivation of the riMLF leads to a loss of all rapid eye movements with an ipsitorsional component (ipsitorsional is defined as movement of the upper pole of the ipsilateral eye in a temporal direction). Vertical eye movements are impaired in an asymmetric way, with downward movements slowed and upward movements little affected. Listing's plane is shifted in the contratorsional direction, i.e., we find a constant torsional offset for all eye positions. With bilateral lesions one observes a total loss of all vertical and torsional eye movements, while Listing's plane retains its shape and position. These results show that burst neurons in the riMLF play a decisive role in generating rapid eye movements with a vertical and torsional component.
内侧纵束吻侧间质核（riMLF）包含爆发神经元，其活动先于具有垂直和/或扭转成分的快速眼动。为了确定它们在共轭眼动产生中的因果作用，我们在该区域进行了单侧和双侧 kainic 酸损伤。riMLF 的单侧失活导致所有具有同侧扭转成分的快速眼动丧失（同侧扭转定义为同侧眼上极向颞侧方向的运动）。垂直眼动以不对称方式受损，向下运动减慢而向上运动几乎不受影响。利斯廷平面向对侧扭转方向偏移，即我们发现所有眼位都有恒定的扭转偏移。双侧损伤时，观察到所有垂直和扭转眼动完全丧失，而利斯廷平面保持其形状和位置。这些结果表明，riMLF 中的爆发神经元在产生具有垂直和扭转成分的快速眼动中起决定性作用。
