阿片类药物对大鼠中枢神经系统中[14C]硫胺掺入的不同影响。
Differential effects of opiates on the incorporation of [14C] thiamine in the central nervous system of the rat.
作者信息
Misra A L, Vadlamani N L, Pontani R B
出版信息
Experientia. 1977 Mar 15;33(3):372-4. doi: 10.1007/BF02002834.
PMID:858372
Abstract
Opiate agonist (morphine), pure antagonist (naloxone), mixed agonist-antagonist (nalorphine) and analgesically inactive enantiomorph (dextrorphan) produced differential stereoselective effects on the incorporation of [14C] thiamine in the central nervous system of the rats. The possible role of thiamine in opiate effects and its implications are discussed.
摘要
阿片类激动剂（吗啡）、纯拮抗剂（纳洛酮）、混合激动-拮抗剂（纳洛芬）和无镇痛活性的对映体（右啡烷）对大鼠中枢神经系统中[14C]硫胺素的掺入产生了不同的立体选择性作用。文中讨论了硫胺素在阿片类作用中的可能作用及其意义。
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