Clauw D J
Georgetown University Medical Center, Washington, DC 20007, USA.
Med Hypotheses. 1995 May;44(5):369-78. doi: 10.1016/0306-9877(95)90263-5.
Syndromes characterized by chronic pain and fatigue have been described in the medical literature for centuries. Fibromyalgia is the term currently used to describe this symptom complex, and considerable research has been performed in the last decade to delineate the epidemiology, pathophysiology, and genesis of this entity. Although fibromyalgia is defined by its musculoskeletal features, it is clear that there are a large number of non-musculoskeletal symptoms, such that we now understand that there is considerable overlap with allied conditions such as the chronic fatigue syndrome, migraine and tension headaches, irritable bowel syndrome, and affective disorders. This article will review our current state of knowledge regarding fibromyalgia and these allied conditions, and present a unifying hypothesis that describes both the pathophysiology of symptoms and the genesis of these disorders.
几个世纪以来，医学文献中一直有关于以慢性疼痛和疲劳为特征的综合征的描述。纤维肌痛是目前用于描述这种症状复合体的术语，在过去十年中已经进行了大量研究，以阐明该实体的流行病学、病理生理学和发病机制。虽然纤维肌痛是由其肌肉骨骼特征定义的，但很明显存在大量非肌肉骨骼症状，因此我们现在明白它与慢性疲劳综合征、偏头痛和紧张性头痛、肠易激综合征以及情感障碍等相关疾病有相当大的重叠。本文将回顾我们目前关于纤维肌痛和这些相关疾病的知识状况，并提出一个统一的假说，该假说描述了症状的病理生理学和这些疾病的发病机制。
