Department of Biomedical Engineering, University of Los Andes, Bogotá, Colombia.
Department of Social Management, Music Therapy Service University Hospital Fundación Santa Fe de Bogotá, Bogotá, Colombia.
Sci Rep. 2024 Oct 9;14(1):23592. doi: 10.1038/s41598-024-73211-3.
Burn patients often face elevated pain, anxiety, and depression levels. Music therapy adds to integrative care in burn patients, but research including electrophysiological measures is limited. This study reports electrophysiological signals analysis during Music-Assisted Relaxation (MAR) with burn patients in the Intensive Care Unit (ICU). This study is a sub-analysis of an ongoing trial of music therapy with burn patients in the ICU. Electroencephalogram (EEG), electrocardiogram (ECG), and electromyogram (EMG) were recorded during MAR with nine burn patients. Additionally, background pain levels (VAS) and anxiety and depression levels (HADS) were assessed. EEG oscillation power showed statistically significant changes in the delta (p < 0.05), theta (p = 0.01), beta (p < 0.05), and alpha (p = 0.05) bands during music therapy. Heart rate variability tachograms high-frequencies increased (p = 0.014), and low-frequencies decreased (p = 0.046). Facial EMG mean frequency decreased (p = 0.01). VAS and HADS scores decreased - 0.76 (p = 0.4) and - 3.375 points (p = 0.37) respectively. Our results indicate parasympathetic system activity, attention shifts, reduced muscle tone, and a relaxed state of mind during MAR. This hints at potential mechanisms of music therapy but needs to be confirmed in larger studies. Electrophysiological changes during music therapy highlight its clinical relevance as a complementary treatment for ICU burn patients.Trial registration: Clinicaltrials.gov (NCT04571255). Registered September 24th, 2020. https//classic.clinicaltrials.gov/ct2/show/NCT04571255.
烧伤患者常面临疼痛加剧、焦虑和抑郁等问题。音乐疗法可以作为烧伤患者整体治疗的辅助手段，但目前相关研究多集中在生理学指标，采用电生理指标的研究较少。本研究报告了烧伤患者在重症监护病房（ICU）接受音乐辅助放松（MAR）时的电生理信号分析。这是一项 ICU 烧伤患者音乐疗法的正在进行的试验的子分析。在 MAR 期间，对 9 名烧伤患者进行了脑电图（EEG）、心电图（ECG）和肌电图（EMG）记录。此外，还评估了背景疼痛水平（VAS）、焦虑和抑郁水平（HADS）。在音乐治疗过程中，脑电图（EEG）的脑电波功率在 delta（p < 0.05）、theta（p = 0.01）、beta（p < 0.05）和 alpha（p = 0.05）频段出现统计学上的显著变化。心率变异性的高频（HF）增加（p = 0.014），低频（LF）减少（p = 0.046）。面部肌电图的平均频率降低（p = 0.01）。VAS 和 HADS 评分分别降低了 -0.76 分（p = 0.4）和 -3.375 分（p = 0.37）。我们的结果表明，在 MAR 过程中，患者的副交感神经系统活动增强、注意力转移、肌肉张力降低，精神状态放松。这提示音乐疗法可能具有潜在的作用机制，但需要在更大的研究中进一步证实。音乐治疗过程中的电生理变化强调了其作为 ICU 烧伤患者补充治疗的临床相关性。试验注册：Clinicaltrials.gov（NCT04571255）。2020 年 9 月 24 日注册。https://classic.clinicaltrials.gov/ct2/show/NCT04571255。
