Zhu Z R, Agren J, Männistö S, Pietinen P, Eskelinen M, Syrjänen K, Uusitupa M
Department of Clinical Nutrition, University of Kuopio, Finland.
Nutr Cancer. 1995;24(2):151-60. doi: 10.1080/01635589509514403.
Fatty acid composition of triglycerides (TGs) and phospholipids (PLs) in breast adipose tissue was analyzed in 73 female breast cancer patients and 55 patients with benign breast disease. No differences were observed in the dietary intake of the major fatty acids (i.e., palmitic, stearic, oleic, and linoleic acids) or in the proportion of TGs and PLs in breast adipose tissue between the two groups. In postmenopausal women, however, the dietary intake of eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) was significantly lower in the breast cancer patients than in patients with benign breast disease. Accordingly, the percentage of docosahexaenoic acid of PLs in breast adipose tissue was significantly lower in breast cancer patients than in patients with benign breast disease among postmenopausal women. The stage of the breast cancer did not contribute to the observed alterations of fatty acid composition of PLs. Consonant with the previous epidemiologic data, the present results suggest that intake of the long-chain n-3 fatty acids (mainly derived from fish) may have a protective effect against breast cancer, particularly in postmenopausal women.
对73例女性乳腺癌患者和55例乳腺良性疾病患者的乳腺脂肪组织中甘油三酯（TGs）和磷脂（PLs）的脂肪酸组成进行了分析。两组在主要脂肪酸（即棕榈酸、硬脂酸、油酸和亚油酸）的饮食摄入量或乳腺脂肪组织中TGs和PLs的比例方面均未观察到差异。然而，在绝经后女性中，乳腺癌患者二十碳五烯酸（20:5n-3）和二十二碳六烯酸（22:6n-3）的饮食摄入量显著低于乳腺良性疾病患者。因此，在绝经后女性中，乳腺癌患者乳腺脂肪组织中PLs的二十二碳六烯酸百分比显著低于乳腺良性疾病患者。乳腺癌的分期对观察到的PLs脂肪酸组成变化没有影响。与先前的流行病学数据一致，目前的结果表明，摄入长链n-3脂肪酸（主要来源于鱼类）可能对乳腺癌具有保护作用，尤其是在绝经后女性中。
