Reiter W, Ehrensberger H, Steinbrückner B, Keller F
Dept. of Medicine, University Hospital, Würzburg, Germany.
Thromb Haemost. 1995 Aug;74(2):596-601.
Underlying disorders of the coagulation system such as inhibitor deficiencies or decreased fibrinolysis are common in patients suffering from venous thrombosis. They may lead to the necessity of a lifelong prophylaxis. Prompt diagnosis is obviously to the patients benefit. We investigated 22 patients suffering from venous thromboses for the inhibitors antithrombin III (ATIII), protein C, and protein S during the first 8 to 12 days after admission to hospital and in addition after withdrawal from anticoagulant treatment after several months. At the day of admission ATIII and protein C levels were comparable to those several months later, but after 2 days they shifted downward or upward, respectively. Protein S did not shift during the period of hospitalisation, but was initially slightly lower than several months later. For inhibitors the day of admission to hospital is most suitable to take the samples. About 50% of the patients still had elevated activation markers (prothrombin fragments F1+2, thrombin-antithrombin complex TAT, and D-dimers) after several months.
凝血系统的潜在疾病，如抑制剂缺乏或纤维蛋白溶解减少，在静脉血栓形成患者中很常见。它们可能导致终身预防的必要性。及时诊断显然对患者有益。我们调查了22例静脉血栓形成患者，在入院后的前8至12天以及几个月后停用抗凝治疗后，检测其抗凝血酶III（ATIII）、蛋白C和蛋白S抑制剂。入院当天，ATIII和蛋白C水平与几个月后相当，但2天后分别下降或上升。住院期间蛋白S水平未发生变化，但最初略低于几个月后。对于抑制剂检测，入院当天最适合采集样本。几个月后，约50%的患者仍有活化标志物（凝血酶原片段F1+2、凝血酶-抗凝血酶复合物TAT和D-二聚体）升高。
