Fitoussi F, Doit C, Sandin A, Pechinot A, Kazmierczack A, Geslin P, Bingen E
Service de Microbiologie, Hôpital Robert Debré, Paris, France.
Antimicrob Agents Chemother. 1995 Nov;39(11):2560-3. doi: 10.1128/AAC.39.11.2560.
An in vitro pharmacodynamic model was used to determine the killing kinetics of cefpirome against 20 Streptococcus pneumoniae strains (penicillin G MICs, > 0.125 to 2 micrograms/ml) isolated from patients with meningitis. The concentration of cefpirome was adjusted dynamically to simulate the median concentration profile obtained in the cerebrospinal fluid of adults after the infusion of a single dose of 2 g. The cefpirome MIC at which 90% of isolates are inhibited was 0.5 microgram/ml. Bactericidal activity was observed at 6 h, with mean killing of 3.51 +/- 0.34 log10 CFU/ml for all strains for which the cefpirome MIC was < 0.5 microgram/ml. In contrast, for strains for which the cefpirome MIC was > or = 0.5 microgram/ml, killing was significantly less (P < 0.05), with a mean reduction of only 2.86 +/- 0.57 log10 CFU/ml.
采用体外药效学模型来确定头孢匹罗对从脑膜炎患者分离出的20株肺炎链球菌（青霉素G的最低抑菌浓度，>0.125至2微克/毫升）的杀菌动力学。动态调整头孢匹罗的浓度，以模拟单剂量输注2克后在成人脑脊液中获得的中位浓度曲线。90%分离株被抑制时的头孢匹罗最低抑菌浓度为0.5微克/毫升。在6小时时观察到杀菌活性，对于头孢匹罗最低抑菌浓度<0.5微克/毫升的所有菌株，平均杀菌量为3.51±0.34 log10 CFU/毫升。相比之下，对于头孢匹罗最低抑菌浓度≥0.5微克/毫升的菌株，杀菌量明显较少（P<0.05），平均仅减少2.86±0.57 log10 CFU/毫升。
