Doit C P, Bonacorsi S P, Fremaux A J, Sissia G, Cohen R, Geslin P L, Bingen E H
Laboratoire de Microbiologie, Hôpital Robert Debré, Paris, France.
Antimicrob Agents Chemother. 1994 Nov;38(11):2655-9. doi: 10.1128/AAC.38.11.2655.
We evaluated the in vitro killing activities of ceftriaxone, imipenem, vancomycin, gentamicin, fosfomycin, and rifampin, alone and in combination, against 26 Streptococcus pneumoniae strains (penicillin G MICs, > 0.125 to 2 micrograms/ml) isolated from the cerebrospinal fluid of children with meningitis. The antibiotics were tested at clinically achievable concentrations in cerebrospinal fluid. After 5 h of incubation, imipenem was the most effective drug. None of the combinations had synergistic activity. Killing by beta-lactam antibiotics or vancomycin was enhanced by the addition of gentamicin, reduced by the addition of rifampin, and unaffected by the addition of fosfomycin.
我们评估了头孢曲松、亚胺培南、万古霉素、庆大霉素、磷霉素和利福平单独及联合使用时，对从患脑膜炎儿童脑脊液中分离出的26株肺炎链球菌（青霉素G的最低抑菌浓度，>0.125至2微克/毫升）的体外杀菌活性。这些抗生素在脑脊液中可达到的临床浓度下进行测试。孵育5小时后，亚胺培南是最有效的药物。没有一种联合用药具有协同活性。添加庆大霉素可增强β-内酰胺类抗生素或万古霉素的杀菌作用，添加利福平则会降低杀菌作用，而添加磷霉素则对杀菌作用无影响。
