脑脊液中临床可达到浓度的抗生素对从脑膜炎患儿分离出的耐青霉素肺炎链球菌的体外杀伤活性。
In vitro killing activities of antibiotics at clinically achievable concentrations in cerebrospinal fluid against penicillin-resistant Streptococcus pneumoniae isolated from children with meningitis.
作者信息
Doit C P, Bonacorsi S P, Fremaux A J, Sissia G, Cohen R, Geslin P L, Bingen E H
机构信息
Laboratoire de Microbiologie, Hôpital Robert Debré, Paris, France.
出版信息
Antimicrob Agents Chemother. 1994 Nov;38(11):2655-9. doi: 10.1128/AAC.38.11.2655.
Abstract
We evaluated the in vitro killing activities of ceftriaxone, imipenem, vancomycin, gentamicin, fosfomycin, and rifampin, alone and in combination, against 26 Streptococcus pneumoniae strains (penicillin G MICs, > 0.125 to 2 micrograms/ml) isolated from the cerebrospinal fluid of children with meningitis. The antibiotics were tested at clinically achievable concentrations in cerebrospinal fluid. After 5 h of incubation, imipenem was the most effective drug. None of the combinations had synergistic activity. Killing by beta-lactam antibiotics or vancomycin was enhanced by the addition of gentamicin, reduced by the addition of rifampin, and unaffected by the addition of fosfomycin.
摘要
我们评估了头孢曲松、亚胺培南、万古霉素、庆大霉素、磷霉素和利福平单独及联合使用时，对从患脑膜炎儿童脑脊液中分离出的26株肺炎链球菌（青霉素G的最低抑菌浓度，>0.125至2微克/毫升）的体外杀菌活性。这些抗生素在脑脊液中可达到的临床浓度下进行测试。孵育5小时后，亚胺培南是最有效的药物。没有一种联合用药具有协同活性。添加庆大霉素可增强β-内酰胺类抗生素或万古霉素的杀菌作用，添加利福平则会降低杀菌作用，而添加磷霉素则对杀菌作用无影响。
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