Kuwert T, Stodieck S R, Puskás C, Diehl B, Puskaś Z, Schuierer G, Vollet B, Schober O
Department of Nuclear Medicine, Westfälische Wilhelms-Universität Münster, Albert-Schweitzer-Strasse 33, D-48129 Münster, Germany.
Eur J Nucl Med. 1996 Jan;23(1):95-8. doi: 10.1007/BF01736996.
Imaging cerebral GABAA receptor density (GRD) with single-photon emission tomography (SPET) and iodine-123 iomazenil is highly accurate in lateralizing epileptogenic foci in patients with complex partial seizures of temporal origin. Limited knowledge exists on how iomazenil SPET compares with magnetic resonance imaging (MRI) in this regard. We present a patient with complex partial seizures in whom MRI had identified an arachnoid cyst anterior to the tip of the left temporal lobe. Contralaterally to this structural abnormality, interictal electroencephalography (EEG) performed after sleep deprivation disclosed an intermittent frontotemporal dysrhythmic focus with slow and sharp waves. On iomazenil SPET images GRD was significantly reduced in the right temporal lobe and thus contralaterally to the MRI abnormality, but ipsilaterally to the pathological EEG findings. These data suggest that iomazenil SPET may significantly contribute to the presurgical evaluation of epileptic patients even when MRI identifies potentially epileptogenic structural lesions.
利用单光子发射断层扫描（SPET）和碘-123异氟烷酯对大脑γ-氨基丁酸A受体密度（GRD）进行成像，在定位颞叶起源的复杂部分性癫痫患者的致痫灶方面具有高度准确性。关于在这方面异氟烷酯SPET与磁共振成像（MRI）相比的情况，目前了解有限。我们报告一名患有复杂部分性癫痫的患者，MRI发现其左颞叶尖端前方有一个蛛网膜囊肿。与这种结构异常相反，睡眠剥夺后进行的发作间期脑电图（EEG）显示出一个间歇性额颞部节律失调灶，伴有慢波和尖波。在异氟烷酯SPET图像上，右侧颞叶的GRD显著降低，因此与MRI异常相反，但与病理性EEG结果同侧。这些数据表明，即使MRI识别出潜在的致痫性结构病变，异氟烷酯SPET也可能对癫痫患者的术前评估有显著贡献。
