Xu M, Deng D, Qin Y, Zhang Z, Yang Z
Hua Xi Yi Ke Da Xue Xue Bao. 1995 Sep;26(3):283-6.
We designed and synthesized twelve new 3,4-dimethoxybenzoyl-piperazine derivatives. These chemical structures (TM-1-TM-12) were confirmed by means of IR, MS, H-NMR and elemental analysis. Compounds (OPC-8212 TM-1, TM-2, VPA) were tested for positive inotropic activity. The results showed that compounds OPC-8212 and VPA possessed positive inotropic activity (P < 0.05). Further pharmacological studies will be made.
我们设计并合成了12种新型3,4-二甲氧基苯甲酰基哌嗪衍生物。这些化学结构（TM-1-TM-12）通过红外光谱（IR）、质谱（MS）、氢核磁共振（H-NMR）和元素分析得以确认。对化合物（OPC-8212、TM-1、TM-2、丙戊酸）进行了正性肌力活性测试。结果表明，化合物OPC-8212和丙戊酸具有正性肌力活性（P<0.05）。将进一步开展药理研究。
