血管紧张素AT2受体基因（Agtr2）与小鼠X染色体的连锁图谱。

Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.

作者信息

Hein L, Dzau V J, Barsh G S

机构信息

Division of Cardiovascular Medicine, Stanford University School of Medicine, California 94305, USA.

出版信息

Genomics. 1995 Nov 20;30(2):369-71. doi: 10.1006/geno.1995.0033.

DOI:10.1006/geno.1995.0033

PMID:8586443

Abstract

Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT1) mediates the cardiovascular actions of angiotensin II, the function of the recently cloned type 2 receptor (AT2) remains unknown. We have cloned the mouse AT2 receptor gene (Agtr2) and determined its map position by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus).Agtr2 is located on the proximal mouse X chromosome between DXMit85 and DXMit49, in a region of conserved synteny with a part of the human X chromosome implicated in inherited forms of premature ovarian failure. The mapping of Agtr2 may expand a region of conserved synteny with human Xq26 that includes Hprt.

摘要

血管紧张素II是心血管稳态的有效调节因子，可与两种不同的G蛋白偶联受体结合。1型受体（AT1）介导血管紧张素II的心血管作用，而最近克隆的2型受体（AT2）的功能尚不清楚。我们克隆了小鼠AT2受体基因（Agtr2），并通过种间回交（C57BL/6J×小家鼠）的连锁分析确定了其图谱位置。Agtr2位于小鼠X染色体近端，在DXMit85和DXMit49之间，与人类X染色体上与遗传性卵巢早衰相关的一部分区域存在保守的同线性。Agtr2的定位可能会扩展与人类Xq26包括次黄嘌呤磷酸核糖转移酶的保守同线性区域。