腺嘌呤核苷酸转位酶2基因（Ant2）在小鼠近端X染色体上的基因定位。

Genetic mapping of the adenine nucleotide translocase-2 gene (Ant2) to the mouse proximal X chromosome.

作者信息

Ellison J W, Salido E C, Shapiro L J

机构信息

Department of Pediatrics, University of California, San Francisco, San Francisco, California, 94143, USA.

出版信息

Genomics. 1996 Sep 1;36(2):369-71. doi: 10.1006/geno.1996.0478.

DOI:10.1006/geno.1996.0478

PMID:8812469

Abstract

Adenine nucleotide translocases are mitochondrial membrane proteins encoded by a small dispersed multigene family. We have previously cloned cDNAs derived from the mouse adenine nucleotide translocase-1 and -2 genes (Ant1 and Ant2) and assigned the loci to mouse chromosomes 8 and X, respectively. Here we describe the genomic organization of the Ant2 gene and its regional map position on the X chromosome, which was determined through linkage analysis using an interspecific backcross between Mus musculus and Mus spretus inbred strains. Ant2 cosegregates with DXMit49 and DXMit50 and lies distal to Agtr2 in the proximal region of the mouse X chromosome. This map assignment further defines a region of conserved synteny between human Xq22-q25 and the mouse proximal X chromosome.

摘要

腺嘌呤核苷酸转位酶是由一个小的分散多基因家族编码的线粒体膜蛋白。我们之前已经克隆了源自小鼠腺嘌呤核苷酸转位酶-1和-2基因（Ant1和Ant2）的cDNA，并分别将这些基因座定位到小鼠的8号和X染色体上。在此，我们描述了Ant2基因的基因组结构及其在X染色体上的区域图谱位置，这是通过使用小家鼠和西班牙小鼠近交系之间的种间回交进行连锁分析确定的。Ant2与DXMit49和DXMit50共分离，位于小鼠X染色体近端区域的Agtr2远端。该图谱定位进一步定义了人类Xq22-q25与小鼠近端X染色体之间保守同线性的区域。