van Soolingen D, Qian L, de Haas P E, Douglas J T, Traore H, Portaels F, Qing H Z, Enkhsaikan D, Nymadawa P, van Embden J D
Laboratory for Bacteriology and Antimicrobial Agents and Unit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
J Clin Microbiol. 1995 Dec;33(12):3234-8. doi: 10.1128/jcm.33.12.3234-3238.1995.
Analysis of the population structure of Mycobacterium tuberculosis strains from the People's Republic of China showed that the vast majority belong to a genetically closely related group. These strains shared the majority of their IS6110 DNA-containing restriction fragments, and also, the DNA polymorphism associated with other repetitive DNA elements, like the polymorphic GC-rich sequence and the direct repeat, was very limited. Because the majority of these strains originated from the province of Beijing, we designated this grouping the "Beijing family" of M. tuberculosis strains. Strains of this family were also found to dominate in neighboring countries such as Mongolia, South Korea, and Thailand, whereas a low prevalence of such strains was observed in countries on other continents. These data indicate that strains of the Beijing family recently expanded from a single ancestor which had a selective advantage. It is speculated that long-term Mycobacterium bovis BCG vaccination may be one of the selective forces implicated in the successful spread of the Beijing genotype.
对来自中华人民共和国的结核分枝杆菌菌株的群体结构分析表明，绝大多数菌株属于基因密切相关的群体。这些菌株共享了它们大多数含IS6110 DNA的限制性片段，而且，与其他重复DNA元件相关的DNA多态性，如富含GC的多态性序列和直接重复序列，非常有限。由于这些菌株大多数来自北京，我们将这个群体命名为结核分枝杆菌菌株的“北京家族”。在蒙古、韩国和泰国等邻国也发现这个家族的菌株占主导地位，而在其他大陆的国家中，此类菌株的流行率较低。这些数据表明，北京家族的菌株最近从具有选择优势的单一祖先扩展而来。据推测，长期的牛型结核分枝杆菌卡介苗接种可能是与北京基因型成功传播相关的选择因素之一。
