West B C, Oberle A D, Kwon-Chung K J
Department of Medicine, Louisiana State University Medical Center, Shreveport 71130, USA.
J Clin Microbiol. 1995 Dec;33(12):3341-4. doi: 10.1128/jcm.33.12.3341-3344.1995.
Mucormycosis accompanied the development of bacterial infection in the leg of a diabetic African-American man. Local injury, diabetic ketoacidosis, renal insufficiency, and antimicrobial therapy were factors that contributed to the pathogenesis of the mucormycosis. The cellulitis was caused in part by Rhizopus microsporus var. microsporus and was cured by amputation. We report this unusual case of mucormycosis to emphasize the value of fungal identification, to illustrate a dramatic and successful clinical result, and to draw attention to an apparent role for bacterial infection and its treatment in the pathogenesis of mucormycosis. It is the third case report of mucormycosis in a human in which R. microsporus var. microsporus was definitively identified as the etiologic agent.
毛霉菌病伴随一名患有糖尿病的非裔美国男性腿部细菌感染而发生。局部损伤、糖尿病酮症酸中毒、肾功能不全以及抗菌治疗是导致毛霉菌病发病的因素。蜂窝织炎部分由微小根毛霉微小变种引起，通过截肢治愈。我们报告这例罕见的毛霉菌病病例，以强调真菌鉴定的价值，说明显著且成功的临床结果，并提请注意细菌感染及其治疗在毛霉菌病发病机制中所起的明显作用。这是第三例明确鉴定微小根毛霉微小变种为病原体的人类毛霉菌病病例报告。
