皮肤利什曼病：葡萄糖酸锑钠病灶内治疗方案
Cutaneous leishmaniasis: schedules for intralesional treatment with sodium stibogluconate.
作者信息
Tallab T M, Bahamdam K A, Mirdad S, Johargi H, Mourad M M, Ibrahim K, el Sherbini A H, Karkashan E, Khare A K, Jamal A
机构信息
Department of Medicine, College of Medicine, King Saud University, Abha Branch, Asir Central Hospital, Kingdom of Saudi Arabia.
出版信息
Int J Dermatol. 1996 Aug;35(8):594-7. doi: 10.1111/j.1365-4362.1996.tb03669.x.
BACKGROUND
Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been investigated.
METHODS
Ninety-six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule.
RESULTS
The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate-day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%.
CONCLUSIONS
Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments.
背景
多种治疗方式已被用于治疗皮肤利什曼病。病灶内注射五价锑剂是有效的治疗方式之一。在本研究中，对三种不同的葡糖酸锑钠病灶内注射方案的疗效进行了研究。
方法
96例患者的129个病灶纳入本研究，所有患者均确诊为皮肤利什曼病。病灶采用三种不同方案治疗，包括每日、隔日和每周进行葡糖酸锑钠病灶内注射。然后比较临床反应以得出最有效的方案。
结果
每日、隔日和每周方案的临床反应（完全治愈和部分治愈）分别为67%、97%和91%。部分治愈或治疗失败的病灶每周注射相同药物，直至完全治愈。完全治愈的最终总体成功率为99.2%。
结论
隔日或每周进行葡糖酸锑钠病灶内治疗皮肤利什曼病比每日治疗更有效。
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