Levesque M, Yu H, D'Costa M, Tadross L, Diamandis E P
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
J Clin Lab Anal. 1995;9(6):375-9. doi: 10.1002/jcla.1860090607.
Prostate-specific antigen (PSA) is a glycoprotein produced by the epithelial cells of the prostate. PSA is currently used clinically to diagnose and monitor prostate carcinoma. In previous work we have demonstrated that 30% of breast tumors and, more rarely other tumors, contain significant amounts of PSA. PSA appears to be a favorable prognostic indicator in breast cancer. Here, using a sensitive assay, we demonstrated for the first time that lung adenocarcinomas and squamous cell carcinomas also contain PSA. PSA in lung tumor extracts was present mainly in its 33 KDa form (free PSA), at levels measurable by commercial methods. The presence of PSA was associated more closely with male patients and adenocarcinomas. The physiological role of PSA in lung tissue and the prognostic significance of PSA in lung cancer remain to be determined. These and our previous data as well as reports by other groups support the view that PSA is a ubiquitous biochemical marker of steroid hormone action.
前列腺特异性抗原（PSA）是一种由前列腺上皮细胞产生的糖蛋白。PSA目前在临床上用于诊断和监测前列腺癌。在之前的研究中，我们已经证明30%的乳腺肿瘤以及更罕见的其他肿瘤中含有大量的PSA。PSA似乎是乳腺癌中一个有利的预后指标。在此，我们使用一种灵敏的检测方法，首次证明肺腺癌和肺鳞状细胞癌中也含有PSA。肺肿瘤提取物中的PSA主要以其33 kDa的形式（游离PSA）存在，其含量可用商业方法检测。PSA的存在与男性患者和腺癌的关系更为密切。PSA在肺组织中的生理作用以及PSA在肺癌中的预后意义仍有待确定。我们的这些数据和之前的数据以及其他研究小组的报告均支持这样一种观点，即PSA是类固醇激素作用的一种普遍存在的生化标志物。
