Yase Y
Research Center of Neurological Diseases, Kansai College of Oriental Medicine.
Nihon Rinsho. 1996 Jan;54(1):123-8.
Although numerous hypotheses have been proposed for the cause of amyotrophic lateral sclerosis (ALS), conclusive decision still remains vague. Recent epidemiological investigation disclosed an aggregation of ALS cases in the Western Pacific, including the Kii Peninsula of Japan, the island of Guam in Marianas and West New Guinea. Extensive environmental studies in these foci indicated an important role of trace elements in ALS etiology. It is postulated that chronic environment deficiencies of calcium and magnesium may provoke secondary hyperparathyroidism, resulting in increased intestinal absorption of toxic metals under the presence of excess levels of divalent or trivalent cations and lead to the mobilization of calcium and metals from the bone and deposition of these elements in nervous tissue. This hypothesis, called metal-induced calcifying degeneration of CNS, has been supported by experimental studies using several animal species.
尽管针对肌萎缩侧索硬化症（ALS）的病因已提出众多假说，但最终结论仍不明确。最近的流行病学调查显示，西太平洋地区存在ALS病例聚集现象，包括日本的纪伊半岛、马里亚纳群岛的关岛和新几内亚西部。对这些地区进行的广泛环境研究表明，微量元素在ALS病因中起着重要作用。据推测，钙和镁的长期环境缺乏可能引发继发性甲状旁腺功能亢进，导致在二价或三价阳离子过量的情况下肠道对有毒金属的吸收增加，并导致钙和金属从骨骼中动员出来并沉积在神经组织中。这一假说，即所谓的金属诱导的中枢神经系统钙化变性，已得到使用多种动物物种的实验研究的支持。
