Mitchell J D
Neurol Clin. 1987 Feb;5(1):43-60.
The first descriptions of the clinical picture of ALS arose from knowledge of the toxic effects of lead on the nervous system. The place of lead in the etiology of ALS remains controversial over 150 years later. More recently, trace element studies have provided a novel approach in our attempts to demonstrate a fundamental metabolic abnormality in motor neurons. The evidence that has been presented in this general area is reviewed in this article.
肌萎缩侧索硬化症临床症状的首次描述源于对铅对神经系统毒性作用的认识。150多年后，铅在肌萎缩侧索硬化症病因学中的地位仍存在争议。最近，微量元素研究为我们试图证明运动神经元存在基本代谢异常提供了一种新方法。本文对该一般领域已提出的证据进行了综述。
